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LimbNET article published in Molecular Systems Biology

After a long time and much work, we are very pleased to announce that our first article1 describing the LimbNET platform has been published today in Molecular Systems Biology: "LimbNET: collaborative platform for simulating spatial patterns of gene networks in limb development".

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Two popular summary articles were also published, the first from EMBL, here, and the second from the PRBB's El·lipse, here.

Article synopsis

LimbNET is a new web application that provides a user-friendly GUI for biologists to share, compare and create hypotheses and dynamic simulations of the gene regulatory networks (GRNs) that control spatial patterning during limb development.

  • A web-based platform was developed for computational modelling of spatiotemporal patterning by gene regulatory networks, in growing limb buds, via an easy-to-use Graphical User Interface.
  • Users can share ideas/hypotheses as computational models, directly integrated with the simulation tools to run them.
  • By providing a straightforward interface for definition and simulation of models, the platform lowers the energy barrier for model development and streamline the modelling process, especially for non-experts.
  • Models are integrated with image-based data in a common platform: an atlas of 2D spatiotemporal gene expression patterns and a repository of models/simulations.

  1. "LimbNET: collaborative platform for simulating spatial patterns of gene networks in limb development", Matyjaszkiewicz A., and Sharpe J., Mol Syst Biol 22, 228–240 (2026) https://doi.org/10.1038/s44320-025-00128-y. ↩